Howard Yi Fan Sim

Title: Howard Yi Fan Sim and His SERS Analysis Platform.

Introduction

Howard Yi Fan Sim is an inventor associated with Nanyang Technological University in Singapore. His patent work describes a surface-enhanced Raman scattering (SERS) platform designed to identify analytes in a sample by generating multiple molecular profiles.

Latest Patents

Sim is associated with 1 patent, titled “Surface-Enhanced Raman Scattering (SERS) Platform for Analysis.” The invention describes a SERS chip with one or more substrates and Raman probes. Each probe uses a SERS-active nanoparticle grafted with a receptor molecule. Different receptor molecules can be used across probes or substrates, enabling the chip to respond to multiple analytes.

When a receptor’s functional group interacts with an analyte, it changes the receptor molecule’s vibration. The resulting change can be detected through SERS, producing profiles that help distinguish analytes. The disclosed method involves exposing the chip to a sample, collecting SERS signals, constructing a combined profile, and providing that profile to a device equipped with a model trained to identify analytes.

Career Highlights

The patent highlights an approach to multiplexed chemical analysis, combining nanoparticle-based sensing with receptor molecules and model-assisted interpretation. The platform is designed to generate information about multiple potential analytes from a single sample.

Collaborations

Sim’s listed coworkers include Xing Yi Ling and In Yee Phang. His institutional affiliation is Nanyang Technological University.

Conclusion

Howard Yi Fan Sim’s patented SERS platform brings together molecular recognition, Raman sensing, and profile-based analysis to support the identification of multiple analytes in a sample.