Howard Smith

Title: Howard Smith: Innovator in Gene Expression Modulation

Introduction

Howard Smith is a notable inventor based in Landsdowne, PA (US). He has made significant contributions to the field of gene expression modulation, holding a total of four patents. His work focuses on innovative methods that enhance the understanding and application of gene regulation in mammalian systems.

Latest Patents

One of Howard Smith's latest patents is titled "Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex." This invention relates to non-steroidal ligands designed for use in a nuclear receptor-based inducible gene expression system. The method involves modulating exogenous gene expression by utilizing an ecdysone receptor complex, which includes a DNA binding domain, a ligand binding domain, a transactivation domain, and a ligand. The process allows for the activation or suppression of the gene by binding the DNA binding domain to a response element in the presence of the ligand.

Career Highlights

Howard Smith is currently employed at Intrexon Corporation, where he continues to advance his research and development efforts. His innovative work has positioned him as a key figure in the biotechnology sector, particularly in the area of gene expression.

Collaborations

Throughout his career, Howard has collaborated with notable colleagues, including Robert Eugene Hormann and Colin M Tice. These partnerships have contributed to the advancement of his research and the successful development of his patents.

Conclusion

Howard Smith's contributions to the field of gene expression modulation through his innovative patents highlight his role as a leading inventor in biotechnology. His work continues to influence the understanding of gene regulation and its applications in various scientific domains.