Howard Robert Clarke

Title: Howard Robert Clarke: Innovator in Recombinant Protein Expression

Introduction

Howard Robert Clarke is an accomplished inventor based in the United States. He has made significant contributions to the field of biotechnology, particularly in the area of recombinant protein expression. His innovative methods have the potential to enhance the efficiency of protein production in various applications.

Latest Patents

Howard Robert Clarke holds a patent titled "Methods For Improving Recombinant Protein Expression Comprising Reduction In Translation Efficiency Of A Selectable Marker Protein." This patent discloses materials and methods that allow for increased expression of a transfected gene of interest in a recombinant host cell. The method involves culturing the host cell, which contains a first heterologous polynucleotide sequence encoding the heterologous protein under conditions that facilitate protein expression. The host cell also comprises a second polynucleotide sequence with a protein coding sequence for a selectable marker protein. The second polynucleotide has a sequence modification compared to a wild-type polynucleotide, which reduces the translation efficiency of the mRNA encoded by the second polynucleotide. This innovative approach provides means of increasing selection pressure on a vector, thereby enhancing vector-associated heterologous protein expression.

Career Highlights

Howard Robert Clarke is currently associated with CMC Icos Biologics, Inc., where he continues to work on advancing biotechnological innovations. His expertise in recombinant protein expression has positioned him as a valuable asset in the field.

Collaborations

Due to space constraints, the collaborations section has been omitted.

Conclusion

Howard Robert Clarke's contributions to recombinant protein expression demonstrate his commitment to advancing biotechnology. His innovative methods have the potential to significantly impact the efficiency of protein production in various applications.