Company Filing History:
Years Active: 2007
Title: Hooman Allayee: Innovator in Atherosclerosis Research
Introduction
Hooman Allayee is a prominent inventor based in Los Angeles, CA. He has made significant contributions to the field of atherosclerosis research, particularly through his innovative patent. His work focuses on the genetic factors contributing to cardiovascular diseases, which are critical for understanding and treating these conditions.
Latest Patents
Hooman Allayee holds a patent titled "Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis." This patent highlights the role of 5-LO, which is expressed in monocyte/macrophages and foam cells of atherosclerotic lesions. His research indicates that 5-LO is differentially expressed in CAST and CON6 mice compared to B6 mice. Notably, mice heterozygous for a null mutation of 5-LO, when placed on an LDLR−/− background, exhibit dramatically reduced atherosclerosis compared to control LDLR mice. Furthermore, a genetic epidemiologic study found a strong association between a common 5-LO polymorphism and carotid artery intima-media thickness (IMT) in coronary artery disease patients. These findings suggest that 5-LO and the leukotriene biosynthetic pathway are major contributors to atherogenesis in animal models and atherosclerosis susceptibility in humans.
Career Highlights
Hooman Allayee is affiliated with the University of California, where he continues to advance research in cardiovascular health. His work has garnered attention for its potential implications in understanding and treating atherosclerosis.
Collaborations
Hooman collaborates with esteemed colleagues, including Margarete Mehrabian and Aldons J Lusis. Their combined expertise enhances the research efforts in the field of atherosclerosis.
Conclusion
Hooman Allayee's innovative research and patent contributions significantly advance our understanding of atherosclerosis and its genetic underpinnings. His work is vital for developing future therapeutic strategies to combat cardiovascular diseases.