University of California

Hooman Allayee

Aldons J Lusis

Margarete Mehrabian

5-LO is expressed in the monocyte/macrophages (mono/mac) and foam cells of atherosclerotic lesions and is differentially expressed in CAST and CON6 mice relative to B6 mice. Mice heterozygous for a null mutation of 5-LO, when placed on an LDLR&#x2212;/&#x2212; background, have dramatically reduced atherosclerosis as compared to control LDLRmice. In a genetic epidemiologic study, it is found that a common 5-LO polymorphism is strongly associated with carotid artery intima-media thickness (IMT) and coronary artery disease patients. These results indicate that 5-LO and the leukotriene biosynthetic pathway is a major contributor to atherogenesis in animal models, and in atherosclerosis susceptibility in humans.

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Hooman Allayee