Company Filing History:
Years Active: 2022-2025
Title: Innovations and Contributions of Inventor Hongxia Wang
Introduction
Hongxia Wang is a notable inventor based in Briarcliff Manor, NY (US). He has made significant contributions to the field of liquid chromatography and mass spectrometry, holding a total of 6 patents. His work focuses on improving compound detection and characterization, which has important implications in various scientific applications.
Latest Patents
One of his latest patents is titled "High confidence compound identification by liquid chromatography-mass spectrometry." This invention discloses methods for enhancing compound detection and characterization. The methods involve providing a sample to a liquid chromatography system capable of sample separation to generate sample components. The sample components are then analyzed by multiplexed targeted selected ion monitoring (SIM) to create an inclusion list. Iterative mass spectral data-dependent acquisition (DDA) is performed from this inclusion list to identify individual sample components, thereby characterizing the sample. This approach is particularly useful for robust compound identification in cell culture medium analysis.
Another significant patent by Wang is "Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor." This invention provides efficient methods to assess the effects of antibody variants, including post-translational modifications such as glycosylation, oxidation, and deamidation, on the binding between the antibody and FcRn. The invention is based on the development of an online, two-dimensional liquid chromatography (2D-LC) method for assessing binding. This method is coupled with mass spectrometry (MS) to differentiate antibody variants by peak pattern and retention time profile through affinity chromatography.
Career Highlights
Hongxia Wang is currently employed at Regeneron Pharmaceuticals, Inc., where he continues to innovate and contribute to advancements in biopharmaceutical research. His expertise in liquid chromatography and mass spectrometry has positioned him as a valuable asset in the field.
Collaborations
Wang has collaborated with notable colleagues, including Haibo Qiu and Ning Li, who have contributed to his research endeavors.
Conclusion
Hongxia Wang's innovative work in liquid chromatography and mass spectrometry has led to significant advancements in compound detection and characterization. His contributions are vital to the ongoing development of biopharmaceuticals and related fields.