Hongling Han

Title: Innovations by Inventor Hongling Han

Introduction

Hongling Han is a notable inventor based in Lexington, MA (US). He has made significant contributions to the field of ion/ion reactions, with a focus on methods and apparatuses that enhance the understanding and application of these reactions. With a total of 2 patents, his work has implications in mass spectrometry and peptide analysis.

Latest Patents

One of his latest patents is titled "Method and apparatus for activation of cation transmission mode ion/ion reactions." This invention discloses a method and apparatus for radial activation of transmission-mode electron transfer ion/ion reactions using a dipolar AC field applied transverse to a transit direction. Increases in fragment ion yields and structural information from electron transfer dissociation (ETD) were observed. This method may be utilized for transmission mode ETD for relatively low charge states of peptides and proteins.

Another significant patent is "Method and apparatus for collisional activation of polypeptide ions." This invention describes a method and apparatus for identifying activating ions through collisions. The method employs a plurality of linear ion taps and various sources of ions along with a mass measuring device. The first source dispenses first ions into a first trap, where they may be kinetically cooled. A second source dispenses second ions into the first trap, where both sets of ions are stored. Ions in the first trap are then ejected to enter a second trap, where they are stored prior to mass spectrometry. The apparatus may utilize quadrupole rods to form the ion traps, with controllable voltage and pressure differences between the traps.

Career Highlights

Hongling Han is associated with the Purdue Research Foundation, where he continues to innovate and contribute to advancements in his field. His work is characterized by a commitment to enhancing the understanding of ion interactions and their applications in scientific research.

Collaborations

He has collaborated with notable colleagues, including Scott A McLuckey and Yu Xia, who have also made significant contributions to the field of mass spectrometry and ion chemistry.

Conclusion

Hongling Han's innovative patents and contributions to the field of ion/ion reactions highlight his role as a leading inventor in scientific research. His work continues to influence advancements in mass spectrometry and peptide analysis.