This inventor holds 2 USPTO granted patents. Top assignees: Bioright Worldwide Company Limited, Other. Active years: 2009-2011.
Company Filing History:
1 out of 7 
1 out of 834,411 Years Active: 2009-2011
Title: Innovations of Hongkin Yap in Enzyme Technology
Introduction
Hongkin Yap is a notable inventor based in Hong Kong, CN. He has made significant contributions to the field of enzyme technology, particularly in the preparation of 7-aminocephalosporanic acid. With a total of 2 patents, his work showcases innovative methods that enhance productivity and efficiency in biochemical processes.
Latest Patents
One of his latest patents is a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C. This invention utilizes a purified D-amino acid oxidase mutant of yeast, which exhibits a specific activity that is 105% higher than that of the parent D-amino acid oxidase. Notably, this method eliminates the need for hydrogen peroxide, β-lactamase inhibitors, and catalase inhibitors, which are commonly used in prior art. The productivity of this method can exceed 93%, making it a simple, cost-effective, and highly productive solution.
Another significant patent by Hongkin Yap involves recombinant D-amino acid oxidases. This invention introduces two novel D-amino acid oxidases that convert cephalosporin C to glutaryl-7-aminocephalosporanic acid with activities at least 25% higher than that of the wild-type D-amino acid oxidase. The encoding DNA sequences of these oxidases are also disclosed, further advancing the field of enzyme technology.
Career Highlights
Throughout his career, Hongkin Yap has worked with various companies, including Bioright Worldwide Company Limited. His innovative approaches and dedication to research have positioned him as a key figure in the development of enzyme applications in pharmaceuticals.
Collaborations
Hongkin Yap has collaborated with notable coworkers such as Waikei Tsang and Jun Wang. Their combined expertise has contributed to the advancement of enzyme technology and its applications in the industry.
Conclusion
Hongkin Yap's contributions to enzyme technology through his innovative patents demonstrate his commitment to enhancing biochemical processes. His work not only improves productivity but also paves the way for future advancements in the field.