Holger Buhler

Title: Holger Buhler: A Pioneer in (S)-Hydroxynitrile Lyases

Introduction

Holger Buhler is a renowned inventor based in Ludwigsburg, Germany, recognized for his significant contributions to the field of biochemistry. His work primarily focuses on the innovative design of enzymes, which play a crucial role in various chemical processes.

Latest Patents

Among his notable achievements, Buhler holds a patent for "(S)-hydroxynitrile lyases with improved substrate acceptance and their use." This invention involves (S)-hydroxynitrile lyases that exhibit enhanced substrate acceptance, achieved by substituting one or more bulky amino acid residues within the hydrophobic channel leading to the active center with less bulky amino acid residues. This advancement has the potential to improve various applications requiring these types of enzymes.

Career Highlights

Holger Buhler is currently affiliated with DSM Fine Chemicals Austria GmbH, a leading company in fine chemical production. His work at this company has allowed him to collaborate with other experts in the field while advancing research in enzymatic applications.

Collaborations

Throughout his career, Buhler has worked alongside notable colleagues such as Franz Effenberger and Harald Wajant. Their collaborative efforts have propelled the study of enzyme functionality and effectiveness, contributing significantly to the development of new biotechnological applications.

Conclusion

As an inventor, Holger Buhler continues to impact the scientific community through his innovative work on (S)-hydroxynitrile lyases. His dedication to improving enzymatic processes showcases the essential role inventors play in advancing technology and research.