Hisaya Azuma

Title: Hisaya Azuma: Innovator in Hepatocyte Expansion

Introduction

Hisaya Azuma is a notable inventor based in Tokyo, Japan. He has made significant contributions to the field of hepatocyte research, particularly through his innovative methods for expanding human hepatocytes in vivo. His work has implications for regenerative medicine and liver disease treatment.

Latest Patents

Hisaya Azuma holds a patent for a method of expanding human hepatocytes in vivo. This method involves using an immunodeficient mouse that is deficient in fumarylacetoacetate hydrolase (Fah). The process includes transplanting human hepatocytes into these specially designed mice, allowing the cells to expand, and subsequently collecting the expanded human hepatocytes. This technique also facilitates serial transplantation into additional mice, enhancing the potential for research and therapeutic applications.

Career Highlights

Throughout his career, Hisaya Azuma has worked with prestigious institutions such as Oregon Health & Science University and Leland Stanford Junior University. His research has focused on advancing the understanding of liver cells and their applications in medicine.

Collaborations

Hisaya Azuma has collaborated with esteemed colleagues, including Markus Grompe and Muhsen Al-Dhalimy. These partnerships have contributed to the advancement of his research and the development of innovative methodologies in hepatocyte expansion.

Conclusion

Hisaya Azuma's work in expanding human hepatocytes represents a significant advancement in medical research. His innovative methods and collaborations continue to pave the way for future developments in regenerative medicine.