Hisao Ona

Title: Hisao Ona - Innovator in Antibacterial Carbapenems

Introduction

Hisao Ona is a notable inventor based in Nara, Japan. He has made significant contributions to the field of medicinal chemistry, particularly in the development of antibacterial agents. His work focuses on the synthesis of halomethylcarbapenems, which are important intermediates in the production of effective antibiotics.

Latest Patents

Hisao Ona holds a patent for the "Process for producing halomethylcarbapenems." This innovative method involves synthesizing 2-halomethylcarbapenem (III) by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent. The resulting product, 2-phosphoryloxymethylcarbapenem (II), is then treated with a halogenating reagent. This process not only provides a functionalized intermediate but also discloses some carbapenems derived from the intermediate.

Career Highlights

Hisao Ona is associated with Shionogi Company Limited, where he continues to advance his research in antibacterial compounds. His expertise in the synthesis of complex molecules has positioned him as a valuable asset in the pharmaceutical industry.

Collaborations

Hisao Ona has collaborated with notable colleagues, including Shoichiro Uyeo and Mitsuru Imuta. These partnerships have fostered a collaborative environment that enhances innovation and research in their field.

Conclusion

Hisao Ona's contributions to the field of antibacterial carbapenems highlight his role as a significant inventor in medicinal chemistry. His innovative processes and collaborations continue to impact the development of effective antibiotics.