Hirokazu Morisawa

Title: Hirokazu Morisawa: Innovator in RNA and Purine Chemistry

Introduction

Hirokazu Morisawa is a notable inventor based in Kawasaki, Japan. He has made significant contributions to the fields of RNA chemistry and purine-arabinoside synthesis. With a total of 3 patents, his work has advanced the understanding and application of nucleic acids in various scientific domains.

Latest Patents

Morisawa's latest patents include innovative compounds for the cleavage at specific positions of RNA. One of his notable inventions discloses a compound composed of an RNA (+chain) and a complementary DNA (-chain). This compound allows for preferential cleavage of the RNA (+chain) at a position corresponding to the unsubstituted portion of the DNA (-chain) when acted upon by an enzyme with ribonuclease H activity. This invention provides a valuable means for preparing deletion mutants. Additionally, he has developed a mixed oligomer that combines RNA or its derivatives with DNA oligomers, linked via a phosphate diester linkage. Another significant patent involves a method for producing purine-arabinosides, which includes contacting an arabinose donor and a purine source in the presence of a specific enzyme, resulting in the production of 9-(.beta.-D-arabinofuranosyl)-purine.

Career Highlights

Throughout his career, Morisawa has worked with prominent companies such as Ajinomoto Co., Ltd. and Asahi Glass Company, Limited. His experience in these organizations has contributed to his expertise in the field of biochemistry and molecular biology.

Collaborations

Morisawa has collaborated with notable coworkers, including Akihiro Yamazaki and Eiko Ohtsuka. These partnerships have likely enriched his research and development efforts.

Conclusion

Hirokazu Morisawa's innovative work in RNA and purine chemistry has led to significant advancements in the field. His patents reflect a deep understanding of molecular interactions and provide valuable tools for scientific research and applications.