Hiroaki Matsumae

Title: Hiroaki Matsumae: Innovator in Optically Active Compounds

Introduction

Hiroaki Matsumae is a distinguished inventor based in Kobe, Japan. He has made significant contributions to the field of chemistry, particularly in the development of optically active compounds. With a total of 5 patents to his name, Matsumae's work has implications for various medicinal applications.

Latest Patents

Matsumae's latest patents include a process for preparing optically active benzothiazepine compounds. This process involves the preparation of a powdery aggregate of 2-phenyl-1,5-benzothiazepin-3,4(2H,5H)-dione compound. The method entails admixing a solution of the compound in a polar organic solvent with a solvent that does not substantially dissolve the compound but is miscible with the polar organic solvent. The resultant particles can be converted into optically active 3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one compounds, which serve as intermediates for various medicaments. Another notable patent is the process for preparing optically active trans-3-phenylglycidamide, which involves optical resolution using a microorganism that preferentially hydrolyzes one of the isomers.

Career Highlights

Matsumae is currently associated with Tanabe Seiyaku Company, Limited, where he continues to innovate in the field of pharmaceuticals. His work has been instrumental in advancing the understanding and application of optically active compounds in medicine.

Collaborations

Matsumae has collaborated with notable colleagues such as Takeji Shibatani and Takuo Nishida. Their combined expertise has contributed to the successful development of various innovative processes and compounds.

Conclusion

Hiroaki Matsumae's contributions to the field of chemistry, particularly in the area of optically active compounds, highlight his role as a significant inventor. His patents and ongoing work at Tanabe Seiyaku Company, Limited, continue to influence the pharmaceutical industry positively.