Hiroaki Kamiyama

Title: Hiroaki Kamiyama: Innovator in Pharmaceutical Chemistry

Introduction

Hiroaki Kamiyama is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of innovative methods for synthesizing complex chemical compounds. With a total of 2 patents to his name, Kamiyama's work is recognized for its potential applications in drug development.

Latest Patents

Kamiyama's latest patents include a method of producing bicyclo[3.1.0] hexane derivative using enzyme. This production method allows for the creation of a bicyclo[3.1.0]hexane derivative, which is useful as a metabotropic glutamate receptor modulator. The method involves converting a compound represented by Formula (II) into a compound represented by Formula (III) through a reaction with an acyl group donor in the presence of a microorganism-derived enzyme. Notably, this process does not require an expensive optically active trans hydroxy ester as a starting material, nor does it involve a fluorination reaction that necessitates ultralow temperature conditions. Additionally, the asymmetric synthesis can be performed closer to the final product, making this method advantageous for mass production.

Another significant patent is the process for producing erythromycin derivative. This preparation process is designed for the efficient synthesis of 6-O-substituted ketolide derivatives. It combines a characterized step of introducing a substituent at the 6-position by selectively cleaving a C—O bond of the cyclic acetal at the 9-position side. This is achieved via a 6,9-cyclic acetal 5-O-desosaminyl erythronolide derivative, followed by conversion into carbonyl groups at the 9- and 3-positions, and culminating in an 11,12-cyclic carbamation to yield 6-O-substituted ketolide derivatives.

Career Highlights

Hiroaki Kamiyama is currently associated with Taisho Pharmaceutical Co., Ltd., where he continues to innovate and contribute to the field of pharmaceutical research. His work is characterized by a commitment to developing efficient and cost-effective synthesis methods that can enhance drug production.

Collaborations

Kamiyama has collaborated with notable colleagues, including Mitsuaki Hirotsuka and Joji Sasaki. These collaborations have further