The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Nov. 19, 2010
Mitsuaki Hirotsuka, Tokyo, JP;
Joji Sasaki, Tokyo, JP;
Hiroaki Kamiyama, Tokyo, JP;
Motoko Oshida, Tokyo, JP;
Takaaki Ishii, Tokyo, JP;
Mitsuaki Hirotsuka, Tokyo, JP;
Joji Sasaki, Tokyo, JP;
Hiroaki Kamiyama, Tokyo, JP;
Motoko Oshida, Tokyo, JP;
Takaaki Ishii, Tokyo, JP;
Taisho Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.