Hilary M Ellis

Title: Hilary M Ellis: Innovator in Recombinant DNA Technology

Introduction

Hilary M Ellis is a prominent inventor based in San Ramon, CA. He has made significant contributions to the field of genetic engineering, particularly in the area of homologous recombination. His work has implications for various applications, including cloning and gene therapy.

Latest Patents

Hilary M Ellis holds a patent for "Enhanced homologous recombination mediated by lambda recombination proteins." This patent discloses methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency homologous recombination in bacterial cells and in eukaryotic cells, such as mammalian cells. These techniques are useful for cloning, generating transgenic and knockout animals, and gene replacement. Additionally, they allow for subcloning large DNA fragments without the need for restriction enzymes. The methods also facilitate the repair of single or multiple base mutations to wild type or the creation of specific mutations in the genome. Furthermore, the patent includes bacterial strains and vectors that are useful for high-efficiency homologous recombination.

Career Highlights

Hilary M Ellis is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this esteemed institution has allowed him to focus on innovative research in genetic engineering and molecular biology.

Collaborations

Some of his notable coworkers include Donald L Court and Daiguan Yu, who have also contributed to advancements in the field of genetic research.

Conclusion

Hilary M Ellis is a key figure in the realm of recombinant DNA technology, with a patent that enhances the efficiency of genetic manipulation. His contributions continue to influence the fields of genetics and biotechnology.