Herbert Waldman

Title: Herbert Waldman: Innovator in Oligonucleotide Synthesis

Introduction

Herbert Waldman is a notable inventor based in Rheinzabern, Germany. He has made significant contributions to the field of oligonucleotide synthesis, holding 2 patents that showcase his innovative approaches.

Latest Patents

Waldman's latest patents focus on nucleosides and nucleoside derivatives. These patents detail a process for the production of oligonucleotides, specifically those where the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine, and 7-deazaguanine carry N-phenylacetyl groups. The process involves binding a starting nucleotide to a solid carrier, followed by the stepwise synthesis of the desired oligonucleotide using activated monomeric nucleotide building blocks. The method also includes the oxidation of trivalent phosphorus to pentavalent phosphorus during and after synthesis, and the subsequent cleavage of the oligonucleotide from the carrier, along with the removal of 5' protecting groups. Notably, the phenylacetyl functional groups can be cleaved off in a mild manner using penicillin amidohydrolase (EC 3.5.1.11).

Career Highlights

Waldman is associated with Boehringer Mannheim GmbH, where he has been able to apply his expertise in nucleoside chemistry and oligonucleotide synthesis. His work has contributed to advancements in the field, particularly in the development of new methodologies for synthesizing complex nucleic acid structures.

Collaborations

Throughout his career, Waldman has collaborated with esteemed colleagues such as Armin Reidel and Axel Heuser. These collaborations have further enriched his research and innovation in the field of oligonucleotide synthesis.

Conclusion

Herbert Waldman's contributions to the field of oligonucleotide synthesis through his patents and collaborations highlight his role as a significant innovator. His work continues to influence advancements in nucleic acid chemistry and biotechnology.