Company Filing History:
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Years Active: 1990-1998
Title: Herbert K Oie: Innovator in Cell Line Development
Introduction
Herbert K Oie is a notable inventor based in Rockville, MD (US), recognized for his contributions to the field of cell line development. He holds two patents that showcase his innovative work in the area of human adrenocortical carcinoma and plasma cell lines. His research has significant implications for cancer treatment and understanding cellular mechanisms.
Latest Patents
Herbert K Oie's latest patents include the development of steroid-secreting human adrenocortical carcinoma cell lines. These continuous cell lines have been established from adrenocortical carcinomas and are maintained in fully defined serum-free, steroid-free mediums. The cells, exemplified by NCI-H295, express all major pathways of steroidogenesis, including the formation of corticosteroids, mineralocorticoids, and androgens. Another significant patent involves a human plasma cell line having a rearranged c-myc proto-oncogene. This cell line, NCI-H929, was established from a malignant effusion in a patient with IgAk myeloma. The cultured cells exhibit the characteristics of plasma cells and synthesize and secrete high amounts of IgAk. They also express surface immunoglobulin and other specific antigens while lacking those associated with earlier stages of B cell development.
Career Highlights
Throughout his career, Herbert K Oie has worked with esteemed organizations, including the United States of America as represented by the Secretary of Health and the Department of Health. His work has contributed to advancements in cancer research and therapeutic development.
Collaborations
Herbert K Oie has collaborated with notable individuals in his field, including Adi F Gazdar and Renato V La Rocca. These collaborations have furthered the research and development of innovative cell lines.
Conclusion
Herbert K Oie's contributions to the field of cell line development have made a significant impact on cancer research. His innovative patents and collaborations highlight his dedication to advancing scientific knowledge and therapeutic options.