Company Filing History:
Years Active: 1976-1982
Title: The Innovations of Herbert H. Silvestri
Introduction
Herbert H. Silvestri is a notable inventor based in DeWitt, NY, with a significant contribution to the field of pharmaceuticals. He holds a total of 8 patents, showcasing his innovative spirit and dedication to advancing medical science. His work primarily focuses on the production of penicillins and cephalosporins, which are crucial in the treatment of various bacterial infections.
Latest Patents
One of Silvestri's latest patents involves the production of penicillins. He developed a method for preparing trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid. This compound is created by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate. This process has proven to be a useful intermediate in the production of penicillins, such as amoxicillin and ampicillin, through its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
Another significant patent pertains to cephalosporin intermediates. In this invention, trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate is prepared similarly by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate. This compound serves as a valuable intermediate in the production of cefadroxil and cephalexin, achieved through its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride.
Career Highlights
Silvestri's career is marked by his association with Bristol-Myers Company, where he has made significant contributions to pharmaceutical research and development. His innovative approaches have led to advancements in antibiotic production, benefiting countless patients worldwide.
Collaborations
Throughout his career, Silvestri has collaborated with notable colleagues, including David A. Johnson and Derek Walker. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.
Conclusion
Herbert H. Silvestri's contributions to the field of pharmaceuticals through his patents and collaborations highlight his role as a key innov