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For the Inventor, By the Inventor

DeWitt, NY, United States of America

Herbert H Silvestri

This inventor holds 8 USPTO granted patents. Top assignee: Bristol-Myers Company. Active years: 1976-1982.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Herbert H Silvestri. Retrieved from https://idiyas.com/inventor/herbert-h-silvestri

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 8

% Patents Active = 100.0

Average Co-Inventor Count = 3.6

ph-index = 2

Forward Citations = 11(Granted Patents)


Company Filing History:

goldMedal8 out of 637 
 
Bristol-Myers Company
 patents

Years Active: 1976-1982

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8 patents (USPTO):Explore Patents
1. 4351766 - Production of penicillins (1982-09-28),
2. 4316017 - Cephalosporin intermediates (1982-02-16),
3. 4316016 - Cephalosporin intermediates (1982-02-16),
4. 4310458 - Production of penicillins (1982-01-12),
5. 4278600 - Production of penicillins (1981-07-14),
6. 4240960 - Trimethylsilyl substituted penicillins (1980-12-23),
7. 4223135 - Production of cephalosporins (1980-09-16),
8. 3941773 - Form II ampicillin (1976-03-02),

Title: The Innovations of Herbert H. Silvestri

Introduction

Herbert H. Silvestri is a notable inventor based in DeWitt, NY, with a significant contribution to the field of pharmaceuticals. He holds a total of 8 patents, showcasing his innovative spirit and dedication to advancing medical science. His work primarily focuses on the production of penicillins and cephalosporins, which are crucial in the treatment of various bacterial infections.

Latest Patents

One of Silvestri's latest patents involves the production of penicillins. He developed a method for preparing trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid. This compound is created by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate. This process has proven to be a useful intermediate in the production of penicillins, such as amoxicillin and ampicillin, through its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.

Another significant patent pertains to cephalosporin intermediates. In this invention, trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate is prepared similarly by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate. This compound serves as a valuable intermediate in the production of cefadroxil and cephalexin, achieved through its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride.

Career Highlights

Silvestri's career is marked by his association with Bristol-Myers Company, where he has made significant contributions to pharmaceutical research and development. His innovative approaches have led to advancements in antibiotic production, benefiting countless patients worldwide.

Collaborations

Throughout his career, Silvestri has collaborated with notable colleagues, including David A. Johnson and Derek Walker. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.

Conclusion

Herbert H. Silvestri's contributions to the field of pharmaceuticals through his patents and collaborations highlight his role as a key innov

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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