Herbert D Soule

Title: The Innovations of Herbert D Soule

Introduction

Herbert D Soule is a notable inventor based in Dearborn, MI (US). He has made significant contributions to the field of biomedical research, particularly in the development of immortalized human mammary epithelial cell lines. With a total of 4 patents, his work has advanced the understanding of epithelial cell growth and its implications in cancer research.

Latest Patents

Soule's latest patents focus on the creation of immortal human mammary epithelial cell lines. These novel cell lines do not undergo terminal differentiation and senescence when exposed to high calcium concentrations. They exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. Importantly, these cells are non-tumorigenic in athymic mice and demonstrate three-dimensional growth in collagen, as well as dome formation in confluent cultures. The cell sublines also show growth control by hormones and growth factors, making them useful for evaluating the effects of preselected agents on epithelial cell growth and protein production.

Career Highlights

Throughout his career, Soule has worked with various organizations, including the Michigan Cancer Foundation. His research has been pivotal in the field of cancer biology, particularly in understanding how epithelial cells behave under different conditions.

Collaborations

Soule has collaborated with notable colleagues such as Robert J Pauley and Terry J Paine. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.

Conclusion

Herbert D Soule's innovative work in the field of biomedical research has led to significant advancements in the understanding of epithelial cell behavior. His contributions continue to impact cancer research and the development of therapeutic strategies.