Herbert Baumann

Title: Herbert Baumann: Innovator in Affinity Ligands and NMR Methods

Introduction

Herbert Baumann is a notable inventor based in Uppsala, Sweden. He has made significant contributions to the field of biochemistry, particularly in the development of affinity ligands and NMR-based methods. With a total of 2 patents, his work has implications for both research and practical applications in various industries.

Latest Patents

Baumann's latest patents include innovative methods and compounds that enhance the efficiency of biochemical assays. One of his patents focuses on the use of urea variants as affinity ligands. This invention relates to an IgG-binding compound that specifically targets human IgGs of κ-type. The compound features an N,N-alkylated urea moiety situated between an aromatic part and a linear or cyclic aliphatic group. This design allows the compound to bind effectively to a pocket-shaped binding site present on all human IgG κ-Fabs, facilitating its use in affinity chromatography and other applications.

Another significant patent involves NMR-based methods for detecting ligands. This invention utilizes hyperpolarized ligands or targets in NMR-based assays, allowing for enhanced sensitivity and accuracy in detecting interactions. The comparison of the NMR spectrum of the ligand or target with a reference spectrum is a key aspect of this method.

Career Highlights

Herbert Baumann has worked with prominent companies in the healthcare sector, including GE Healthcare and GE Healthcare Bio-Sciences. His experience in these organizations has contributed to his expertise in developing innovative solutions in biochemistry and molecular biology.

Collaborations

Throughout his career, Baumann has collaborated with notable professionals in his field, including Jan-Henrik Ardenkjaer-Larsen and Graham John Cotton. These collaborations have likely enriched his research and led to advancements in his patented technologies.

Conclusion

Herbert Baumann's contributions to the fields of affinity ligands and NMR methods demonstrate his innovative spirit and commitment to advancing biochemistry. His patents reflect a deep understanding of molecular interactions and their applications in scientific research.