Company Filing History:
Years Active: 2020-2022
Title: Henry Hung-yi Lee: Innovator in Gene Expression and Nucleic Acid Synthesis
Introduction
Henry Hung-yi Lee is a prominent inventor based in Brookline, MA (US). He has made significant contributions to the fields of gene expression and nucleic acid synthesis. With a total of 4 patents, his work has advanced scientific understanding and practical applications in biotechnology.
Latest Patents
One of his latest patents is focused on a method of regulating gene expression in a cell. This patent provides methods for creating a tetracycline inducible expression system in a cell. The methods involve providing the cell with a first nucleic acid sequence that includes a first promoter linked to a tetracycline repressor gene coding sequence. Additionally, a second nucleic acid sequence is provided, which comprises a second promoter linked to a coding sequence of a gene of interest. This second promoter is modified to include one or more tetracycline repressor protein binding sites. The expression of the gene of interest can then be determined in the presence or absence of tetracycline.
Another significant patent by Lee is related to enzymatic nucleic acid synthesis. This patent outlines methods for making a polynucleotide where the addition of nucleotides can be controlled physically, chemically, and/or enzymatically. The methods include combining a selected nucleotide, cations, and an error-prone or template-independent DNA polymerase at a reaction site. This innovative approach allows for the covalent addition of nucleotides to form the desired polynucleotide.
Career Highlights
Henry Hung-yi Lee is affiliated with Harvard College, where he continues to contribute to research and innovation in his field. His work has garnered attention for its potential applications in genetic engineering and synthetic biology.
Collaborations
Lee has collaborated with notable scientists such as George M. Church and Reza Kalhor. These collaborations have further enriched his research and expanded the impact of his inventions.
Conclusion
Henry Hung-yi Lee is a distinguished inventor whose work in gene expression and nucleic acid synthesis has made a significant impact in biotechnology. His innovative patents and collaborations highlight his contributions to advancing scientific knowledge and practical applications.