Company Filing History:
Years Active: 2019-2025
Title: Innovations of Henry Brinkerhoff in Nanopore Technology
Introduction
Henry Brinkerhoff is an accomplished inventor based in Seattle, WA. He has made significant contributions to the field of nanopore technology, particularly in the analysis of nucleic acids and proteins. With a total of 5 patents to his name, Brinkerhoff's work is at the forefront of scientific innovation.
Latest Patents
Brinkerhoff's latest patents include groundbreaking methods for improved nanopore-based analysis of nucleic acids. One of his notable inventions involves a computer-implemented method for determining the identity of monomer subunit residues of a polymer analyte. This method utilizes a raw current signal generated by applying a variable voltage to translocate the polymer through a nanopore. Additionally, he has developed techniques for detecting change points in the raw current signal to determine a series of states. His work also includes capacitance compensation on the raw current signal, creating ionic current-vs-voltage curves, which are then converted to conductance-vs-voltage curves. Furthermore, filtering is performed to create a series of filtered states, ultimately determining the identity of the polymer analyte's monomer subunit residues.
Another significant patent focuses on nanopore-based analysis of protein characteristics. This method addresses the characterization of a target protein analyte that is physically associated with a polymer and has a dimension greater than the internal diameter of the nanopore tunnel. By applying an electrical potential to the nanopore system, the polymer interacts with the nanopore tunnel, allowing for the measurement of ion current. This current pattern serves as a metric for characterizing the associated protein that does not pass through the nanopore.
Career Highlights
Henry Brinkerhoff is affiliated with the University of Washington, where he continues to advance research in nanopore technology. His innovative approaches have garnered attention in the scientific community, contributing to the understanding of molecular interactions at the nanoscale.
Collaborations
Brinkerhoff has collaborated with notable researchers such as Jens H Gundlach and Ian M Derrington. Their combined expertise has further propelled advancements in nanopore technology and its applications.
Conclusion
Henry Brinkerhoff's contributions to nanopore technology exemplify the intersection of innovation and scientific research. His patents not only enhance our understanding of nucleic acids and proteins but also pave the way for future advancements in the field.