Henricus Jm Van Blokland

Title: Henricus Jm Van Blokland: Innovator in Genetic Engineering

Introduction

Henricus Jm Van Blokland is a notable inventor based in Wijdewormer, Netherlands. He has made significant contributions to the field of genetic engineering, particularly in the development of methods for selecting host cells that express proteins at high levels. His innovative work has led to the filing of a patent that showcases his expertise and creativity in this area.

Latest Patents

Henricus Jm Van Blokland holds a patent titled "Selection of host cells expressing protein at high levels." This patent describes a DNA molecule that comprises an open reading frame sequence encoding a selectable marker polypeptide. The DNA molecule includes a translation start sequence for the selectable marker polypeptide with a GTG or TTG start codon. Additionally, the open reading frame sequence has been mutated to replace at least half of its CpG dinucleotides compared to the native sequence. The patent also outlines methods for obtaining host cells that express a polypeptide of interest, which involves culturing host cells that contain the described DNA molecules.

Career Highlights

Henricus Jm Van Blokland is associated with Chromagenics B.V., where he applies his knowledge and skills in genetic engineering. His work at the company has been instrumental in advancing the field and contributing to innovative solutions in biotechnology.

Collaborations

Henricus has collaborated with notable colleagues, including Arie Pieter Otte and Theodorus Hendrikus Jacobus Kwaks. These collaborations have fostered a productive environment for innovation and research.

Conclusion

Henricus Jm Van Blokland is a distinguished inventor whose work in genetic engineering has led to valuable advancements in the selection of host cells for protein expression. His contributions continue to impact the field positively.