Years Active: 2001
Title: Innovations in Chemotherapy Delivery: The Work of Henny Brem
Introduction
Henny Brem is a pioneering inventor based in Lutherville, MD (US), known for her significant contributions to the field of localized chemotherapy delivery. Her innovative approach addresses the challenges associated with treating solid tumors, particularly those that do not respond well to conventional methods.
Latest Patents
Brem holds a patent for a method and devices designed for the controlled local delivery of chemotherapeutic agents for treating solid tumors. This patent describes a system that allows for the localized delivery of a chemotherapeutic agent, which does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo. The devices consist of reservoirs that release the drug over an extended time period while preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrices, although reservoirs can also be formulated from non-biodegradable polymers or connected to implanted infusion pumps. These devices are implanted within or immediately adjacent to the tumors to be treated or the site from which they have been surgically removed. The examples provided in her patent demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results of these studies are highly statistically significant.
Career Highlights
Henny Brem's career is marked by her dedication to advancing cancer treatment methodologies. Her innovative work has not only contributed to the scientific community but has also provided new hope for patients suffering from solid tumors.
Collaborations
Brem has collaborated with notable figures in the field, including Robert Samuel Langer and Abraham Domb. These partnerships have further enhanced the impact of her research and innovations.
Conclusion
Henny Brem's contributions to the field of localized chemotherapy delivery represent a significant advancement in cancer treatment. Her patented methods and devices offer promising solutions for effectively targeting solid tumors, showcasing her role as a leading inventor in this critical area of medical research.