Hendrikus J Eggelte

Title: Hendrikus J Eggelte: Innovator in Hydrolase Enzyme Detection

Introduction

Hendrikus J Eggelte is a notable inventor based in Brunswick Square, GB. He has made significant contributions to the field of biochemistry, particularly in the detection of hydrolase enzymes. His innovative approach has led to the development of a unique amplification assay that enhances the sensitivity of enzyme detection.

Latest Patents

Hendrikus J Eggelte holds a patent for an "Amplification assay for hydrolase enzymes." This patent describes a method for sensitively determining hydrolase enzymes using novel substituted FAD substrates. The substituted FAD substrates are hydrolyzed to FAD by the enzyme being detected. The FAD is then combined with an apoenzyme to form a holoenzyme, which initiates a reaction leading to a detectable product. When the hydrolase to be detected is phosphatase, the novel substrate is a phosphorylated derivative of FAD. A suitable apoenzyme for this process is apo-glucose oxidase, which provides exceptional sensitivity. Additionally, apo-D-amino acid oxidase can be utilized in a 'single pot' assay system.

Career Highlights

Hendrikus J Eggelte is associated with London Biotechnology Limited, where he applies his expertise in enzyme detection. His work has been instrumental in advancing methodologies that improve the accuracy and sensitivity of biochemical assays. His innovative contributions have garnered attention in the scientific community.

Collaborations

Hendrikus has collaborated with notable colleagues, including Brian R Rabin and Stuart Harbron. These collaborations have further enriched his research and development efforts in the field of biochemistry.

Conclusion

Hendrikus J Eggelte's work in the amplification assay for hydrolase enzymes represents a significant advancement in enzyme detection technology. His innovative methods and collaborations continue to influence the field positively.