Helen Hsieh

Title: Innovations by Helen Hsieh in Biocatalysis

Introduction

Helen Hsieh is a prominent inventor based in Singapore, known for her significant contributions to the field of biocatalysis. With a total of 12 patents to her name, she has made remarkable advancements in the synthesis of chiral amines and substituted lactams. Her work is instrumental in the development of active pharmaceutical agents.

Latest Patents

One of her latest patents focuses on engineered biocatalysts and methods for synthesizing chiral amines. This patent provides engineered transaminase polypeptides for the production of amines, along with polynucleotides encoding these engineered transaminases. It also includes host cells capable of expressing the engineered transaminases and methods for using them to prepare compounds useful in the production of active pharmaceutical agents. Another notable patent relates to biocatalysts and methods for the synthesis of substituted lactams. This disclosure involves transaminase polypeptides that can aminate a dicarbonyl substrate, along with polynucleotides, vectors, host cells, and methods for making and using these transaminase polypeptides.

Career Highlights

Helen Hsieh is currently employed at Codexis, Inc., where she continues to innovate and develop new biocatalytic processes. Her expertise in the field has positioned her as a leader in biocatalysis research.

Collaborations

Helen has collaborated with notable colleagues, including Weng Lin Tang and Son Pham, to further enhance the research and development of biocatalysts.

Conclusion

Helen Hsieh's contributions to biocatalysis through her innovative patents and collaborations highlight her role as a key figure in advancing pharmaceutical synthesis. Her work continues to impact the field significantly.