Company Filing History:
Years Active: 2006-2009
Title: Heather Ramshaw: Innovator in Cytochrome P450 Research
Introduction
Heather Ramshaw is a prominent inventor based in Napanee, Canada. She has made significant contributions to the field of biochemistry, particularly in the study of cytochrome P450 enzymes. With a total of four patents to her name, her work focuses on the metabolic processes related to all-trans-retinoic acid (RA) and its implications in various health conditions.
Latest Patents
Among her latest patents is the invention of P450RAI-2, a novel all-trans-RA inducible cytochrome P450. This enzyme is predominantly expressed in the brain, particularly in the cerebellum, and is also found in normal and tumor lung tissue as well as breast cancer cells. The invention details how human P450RAI-2 shows 42% amino acid identity to human P450RAI-1. When transfected into COS-1 cells, it facilitates the rapid conversion of all-trans-RA into more polar metabolites, including inactive products such as 4-oxo-RA, 4-OH-RA, and 18-OH-RA. The methods and uses of this new polynucleotide and polypeptide include potential treatments for dermatological disorders, cancer, and certain brain disorders.
Career Highlights
Heather Ramshaw is currently associated with Cytochroma Inc., where she continues her research and development in the field of cytochrome P450 enzymes. Her innovative work has positioned her as a key figure in the scientific community, particularly in the study of metabolic pathways and their implications for health.
Collaborations
Throughout her career, Heather has collaborated with notable colleagues, including Martin Petkovich and Jay A White. These collaborations have further enhanced her research and contributed to the advancement of knowledge in her field.
Conclusion
Heather Ramshaw's contributions to the field of biochemistry, particularly through her patents related to cytochrome P450 enzymes, highlight her role as an influential inventor. Her work not only advances scientific understanding but also holds promise for future medical applications.
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