Haruo Saito

Title: Haruo Saito: Innovator in T Lymphocyte Receptor Technology

Introduction

Haruo Saito is a prominent inventor based in Arlington, MA (US), known for his significant contributions to the field of immunology. He holds a total of 7 patents, focusing primarily on T lymphocyte receptor technology. His work has advanced the understanding of T cell receptors, which play a crucial role in the immune response.

Latest Patents

Saito's latest patents include the development of a heterodimeric T lymphocyte receptor subunit. This invention discloses a subunit that consists of variable, joining, constant, transmembrane, and cytoplasmic regions. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor subunit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and exhibit significant sequence homologies to immunoglobulin V and C genes. Additionally, T cell receptor subunits may be produced from the cDNA clones, and the protein molecules may be further utilized for the production of T-cell clone specific antibodies.

Career Highlights

Throughout his career, Haruo Saito has worked with prestigious institutions such as the Massachusetts Institute of Technology and Leland Stanford Junior University. His research has contributed to the advancement of immunological studies and the development of therapeutic applications.

Collaborations

Saito has collaborated with notable scientists, including David M. Kranz and Herman N. Eisen. These collaborations have further enriched his research and innovations in the field.

Conclusion

Haruo Saito's work in T lymphocyte receptor technology has made a significant impact on immunology. His patents and collaborations reflect his dedication to advancing scientific knowledge and developing new therapeutic strategies.