Location History:
- Bethesda, MD (US) (2001)
- Chevy Chase, MD (US) (1992 - 2010)
Company Filing History:
7 out of 3,539 
5 out of 1,217 
3 out of 2,202 
Years Active: 1992-2010
Title: The Innovations of Harry V Gelboin
Introduction
Harry V Gelboin is a prominent inventor based in Chevy Chase, MD (US). He has made significant contributions to the field of biochemistry, particularly in the study of cytochrome P450 enzymes. With a total of 16 patents, Gelboin's work has advanced our understanding of drug metabolism and its implications for personalized medicine.
Latest Patents
Among his latest patents, Gelboin has developed agents that bind to and inhibit human cytochrome P450 2C19. This invention provides monoclonal antibodies and other binding agents that substantially inhibit the enzyme activity of human cytochrome P450 2C19 while lacking specific binding to other human cytochrome P450s. These binding agents are useful in methods for screening drugs for metabolism by cytochrome P450 2C19 and in measuring P450 2C19 levels in individuals compared to a control population. Additionally, he has created antibodies that bind to and inhibit human cytochrome P450 2C9*1, 2C9*2, and 2C9*3. This invention also includes monoclonal antibodies and binding agents that inhibit enzyme activity across various human cytochrome P450 2C family members, aiding in drug screening and identifying poor metabolizing phenotypes.
Career Highlights
Gelboin's career has been marked by his association with the United States of America as represented by the Department of Health and the National Institutes of Health, a component of the US Department of Health & Human Services. His work has been instrumental in advancing the field of pharmacogenomics, which studies how genes affect a person's response to drugs.
Collaborations
Throughout his career, Gelboin has collaborated with notable colleagues, including Frank J Gonzalez and Kristopher W Krausz. These collaborations have further enriched his research and contributed to the development of innovative solutions in drug metabolism.
Conclusion
Harry V Gelboin's contributions to the field of biochemistry and pharmacogenomics have had a lasting impact on drug development and personalized medicine. His innovative patents and collaborations continue to influence research and clinical practices today.