The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2009
Filed:
Jul. 09, 2003
Harry V. Gelboin, Chevy Chase, MD (US);
Kristopher W. Krausz, Columbia, MD (US);
Frank J. Gonzalez, Bethesda, MD (US);
Harry V. Gelboin, Chevy Chase, MD (US);
Kristopher W. Krausz, Columbia, MD (US);
Frank J. Gonzalez, Bethesda, MD (US);
United States of America as represented by Department of Health and Human Services, Washington, DC (US);
Abstract
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C family members, and in methods of screening individuals for a poor metabolizing individual human P450 2C family phenotypes.