Location History:
- Miami, FL (US) (1980 - 1990)
- Pembroke Pines, FL (US) (1984 - 1999)
Company Filing History:
Years Active: 1980-1999
Title: **Harold R. Crews: A Pioneer in Enzymatic Activity and Leukemia Detection**
Introduction
Harold R. Crews, located in Miami, FL, is a distinguished inventor with a remarkable portfolio of 19 patents. His innovative contributions have significantly advanced the fields of enzymatic assays and leukemia diagnosis. Crews' inventions not only enhance the detection and analysis processes but also improve the accuracy and efficiency of medical assessments.
Latest Patents
Among Harold R. Crews' most notable patents are innovations that focus on enzymatic activity and leukemia detection. One of his latest inventions is a cell control used to confirm enzymatic activity. This invention provides a cell control product designed for use in cytoenzymology assays, enabling accurate confirmation of enzymatic activity through electronic and optical means. The product comprises a lyophilized mammalian cell that can be rehydrated to exhibit both cellular structure and enzymatic activity, functioning reliably in enzymatic analyses. The cellular structure can be authenticated using light scatter or microscopy analysis, while enzymatic activity can be verified through fluorescence analysis. The cell control showcases real-time stability when stored between 2 and 8 degrees Celsius for at least two months, with a preference for abnormal mammalian cells from cell lines such as Molt 4, CCRF-CEM, and HL-60.
Another significant patent pertains to the identification of blast cells in a leukocyte cell preparation. This method addresses the critical need for detecting blast cells in patient samples, essential for determining treatment regimens for leukemia. Crews' method offers a rapid means for identifying blast cells and determining their lineage, markedly improving the efficiency compared to prior techniques.
Career Highlights
Harold R. Crews has built an impressive career, working with companies known for their dedication to technological advancements. He has made significant contributions during his tenure at Coulter Electronics, Inc. and Coulter International Corporation. His work has greatly influenced the development of diagnostic technologies in the medical field.
Collaborations
Throughout his career, Crews has collaborated with notable professionals in his field, including colleagues Stephen L. Ledis and James H. Carter. These collaborations have played a vital role in the innovation process, allowing for the exchange of ideas and expertise that fostered the development of groundbreaking technologies.
Conclusion
Harold R. Crews stands out as a visionary inventor whose contributions have had a lasting impact on the fields of enzymatic activity and leukemia detection. With a solid foundation built on dedication and innovation, Crews' work continues to influence modern medical diagnostics, showcasing the importance of inventive thinking in improving healthcare outcomes. His 19 patents are a testament to his ingenuity and commitment to advancing technology for the betterment of society.