Harold L Daughety

Title: Harold L Daughety: Innovator in Cyclopropylamine Manufacturing

Introduction

Harold L Daughety is a notable inventor based in Baton Rouge, Louisiana. He has made significant contributions to the field of chemical manufacturing, particularly in the production of cyclopropylamine. His innovative processes have paved the way for advancements in this area of chemistry.

Latest Patents

Daughety holds a patent for a novel process for the manufacture of cyclopropylamine. This process involves a modified method for preparing cyclopropylamine from gamma-butyrolactone. The method includes cleaving the gamma-butyrolactone ring with a hydrohalide in the presence of a unique catalyst, which is an aqueous sulfuric acid solution. The resulting 4-chlorobutyric acid is then converted into a hindered chlorobutyrate ester. This ester, based on secondary and tertiary alkanols with eight or fewer carbon atoms, is cyclized to form a hindered cyclopropanecarboxylate ester using a novel reaction medium. The final steps involve ammoniating the hindered cyclopropanecarboxylate ester to form cyclopropanecarboxamide, which is then converted to cyclopropylamine through a modified Hofmann reaction.

Career Highlights

Daughety has had a distinguished career at Ciba-Geigy Corporation, where he has applied his expertise in chemical processes. His work has not only contributed to the company's success but has also advanced the field of organic chemistry.

Collaborations

Throughout his career, Daughety has collaborated with notable colleagues, including Joseph T Blackwell, III and Henry C Grace. These collaborations have fostered innovation and have led to significant advancements in their respective fields.

Conclusion

Harold L Daughety's contributions to the manufacturing of cyclopropylamine highlight his innovative spirit and dedication to advancing chemical processes. His work continues to influence the industry and inspire future innovations.