Hansol Park

Title: Hansol Park and a DNA Ligation Method for Detecting Abasic Sites.

Introduction

Hansol Park is an inventor located in Toronto, Canada. His work includes a patent describing a ligation-based method for detecting abasic sites in DNA target sequences. The patent record provided lists 1 patent for him.

Latest Patents

The patent, “Method of ligation for the detection of abasic sites on a DNA target sequence,” describes joining a pyrene probe to a second probe in the presence of a ligase. The pyrene probe may include a 5′-phosphate 1′-pyrene deoxyribonucleotide at its 5′ terminus, while the second probe may have a terminal 3′-hydroxy group that ligates with it.

The method may use T4 DNA Ligase or PBCV-1 ligase, with PBCV-1 reported to improve selectivity. The target’s abasic site may occur naturally or be generated through the addition of an enzyme. The description also identifies adenosine triphosphate (ATP) and ligation at temperatures above the probe–target sequence’s thermal dissociation temperature as ways to increase selectivity.

Career Highlights

The available information highlights Park’s contribution to a molecular detection technique focused on identifying abasic sites in DNA. The method uses probe design and ligation conditions to support selective detection.

Collaborations

The supplied information names Julianne M. Gibbs-Davis as Park’s coworker. No further details about their collaboration are provided.

Conclusion

Hansol Park’s listed patent describes a probe-ligation approach for detecting abasic sites in DNA, with potential selectivity improvements through ligase choice and reaction conditions.