Hansjörg Toll

Title: Innovations by Hansjörg Toll

Introduction

Hansjörg Toll is a notable inventor based in Kundl, Austria. He has made significant contributions to the field of biotechnology, particularly in the optimization of coding sequences for polynucleotides. His work has implications for the engineering of polypeptides, which are essential in various biotechnological applications.

Latest Patents

Hansjörg Toll holds a patent related to sequence variants. The patent, titled "Amino acid residue misincorporations are necessarily found in sequence variants at low concentrations in admixture with expressed polypeptides," addresses the challenges posed by base mismatches within codons. This invention provides a method for optimizing coding sequences of polynucleotides that encode polypeptides, particularly those susceptible to amino acid residue misincorporation. The method can also be utilized to reverse-engineer unknown coding sequences and alter the immunogenic potential of expressed polypeptides. This innovation is crucial for engineering optimized polynucleotides.

Career Highlights

Hansjörg Toll is associated with Sandoz AG, a leading global healthcare company. His work at Sandoz AG has allowed him to focus on advancements in biotechnology and contribute to the development of innovative solutions in the field.

Collaborations

Throughout his career, Hansjörg Toll has collaborated with notable colleagues, including Johann Holzmann and Michael Fuchs. These collaborations have fostered a productive environment for innovation and research.

Conclusion

Hansjörg Toll's contributions to biotechnology, particularly through his patent on optimizing coding sequences, highlight his role as an influential inventor in the field. His work continues to impact the development of engineered polynucleotides and polypeptides, showcasing the importance of innovation in biotechnology.