Company Filing History:
Years Active: 1987-1993
Title: **Inventor Hans-Otto Beutler: Innovations in Enzymatic Reagents**
Introduction
Hans-Otto Beutler, an accomplished inventor based in Tutzing, Germany, has garnered recognition for his valuable contributions to the field of enzymatic reagents. With a portfolio of four patents, Beutler's innovations have significant implications for biochemical analysis and research.
Latest Patents
Among his notable inventions is a groundbreaking enzymatic reagent for the determination of D-malate. This invention introduces a new NAD⁺-dependent D-malate dehydrogenase (decarboxylating, E.C. 1.1.1.83) derived from E. coli. The enzyme consists of two subunits, each roughly 42 kD in molecular weight (SDS gel). Additionally, it outlines processes for isolating and stabilizing the enzyme, alongside a novel method for D-malate determination facilitated by this enzyme reagent.
Another significant patent by Beutler is for a stabilized, NAD(P)H-dependent, soluble nitrate reductase of the assimilatory type. This patent presents a solution characterized by a molecular weight of approximately 90,000 D when analyzed via electrophoresis with sodium dodecyl sulfate. It boasts more than 60% residual activity after three weeks at 35°C, obtainable through a detailed process involving tris/tartaric acid buffer, soluble polyethyleneimine, and conventional biochemical fractionation methods.
Career Highlights
Hans-Otto Beutler has made substantial advancements in enzymology during his tenure at Boehringer Mannheim GmbH. His work focuses on the development and stabilization of enzymes that enhance analytical processes in biochemistry, a testament to his expertise and innovative spirit.
Collaborations
Beutler has had the opportunity to collaborate with notable scientists in his field, including Ulfert Deneke and Gerhard Micharl. These partnerships reflect a collaborative effort to push the boundaries of scientific knowledge and innovation in enzymatic research.
Conclusion
Hans-Otto Beutler continues to be a key figure in the field of enzyme research, contributing innovations that facilitate more accurate biochemical determinations. His patents exemplify a blend of creativity and scientific rigor, marking him as an inventor to watch in the evolving landscape of biochemistry.
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