Location History:
- Ruysdaellaan, NL (1998)
- Huis ter Heide, NL (1999)
Company Filing History:
2 out of 3 
1 out of 3,687 
Years Active: 1998-1999
Title: Innovations and Contributions of Hans Clevers
Introduction
Hans Clevers is a prominent inventor known for his significant contributions to cancer research. He is based in Ruysdaellaan, Netherlands, and has been instrumental in advancing our understanding of tumor suppressor proteins and their interactions. With a total of two patents to his name, Clevers has made remarkable strides in the field of molecular biology.
Latest Patents
One of Hans Clevers' latest patents focuses on the interaction between the APC tumor suppressor protein and .beta.-catenin. This research highlights how .beta.-catenin interacts with Tcf/Lef transcription factors, specifically the gene encoding a Tcf family member expressed in colonic epithelium, known as hTcf-4. The findings indicate that hTcf-4 can transactivate transcription only when associated with .beta.-catenin. In APC-deficient colon carcinoma cells, a stable .beta.-catenin-hTCF-4 complex was found to be constitutively active, leading to the transcription of Tcf target genes. The reintroduction of APC was shown to remove .beta.-catenin from hTcf4, thereby abrogating transcriptional transactivation. This research underscores the critical role of .beta.-catenin regulation in APC's tumor suppressive effect and how mutations in either APC or .beta.-catenin can circumvent this regulation.
Career Highlights
Hans Clevers has had a distinguished career, contributing to various research institutions. He has worked at Utrecht University and The Johns Hopkins University, where he has collaborated with leading scientists in the field. His work has not only advanced scientific knowledge but has also paved the way for potential therapeutic strategies in cancer treatment.
Collaborations
Throughout his career, Hans Clevers has collaborated with notable researchers, including Nick Barker and Kenneth W Kinzler. These collaborations have further enriched his research and contributed to significant advancements in cancer biology.
Conclusion
Hans Clevers is a key figure in cancer research, with innovative patents that explore the intricate mechanisms of tumor suppression. His work continues to influence the scientific community and offers hope for future cancer therapies.