Hanbin Mao

Title: Innovations of Hanbin Mao in Biosensing Technologies

Introduction

Hanbin Mao is a prominent inventor based in Kent, OH (US), known for his significant contributions to the field of biosensing technologies. With a total of 3 patents, Mao has developed innovative solutions that leverage DNA origami nanostructures for high-throughput mechanochemical biosensing.

Latest Patents

Mao's latest patents include a mechanochemical platform and sensing methods using DNA origami nanostructures. This biosensing platform is capable of high throughput mechanochemical biosensing, comprising a DNA origami nanostructure with multiple slots for strategically placed recognition elements. The apparatus senses changes in the origami nanostructure in response to target introductions, utilizing a signal transduction unit and signal sensor that exploits mechanical signals. The nanostructure is designed as a 2-dimensional or 3-dimensional arrangement of tiles linked by locking elements, such as aptamers, which respond to events like exposure to drug molecules, DNA, RNA, or protein targets.

Another notable patent is the single-molecule mechanoanalytical DNA device for ultrasensitive sensing of analytes. This device, known as SMART, features a molecular trawl and a DNA stem-loop structure that acts as a molecular dipstick. The molecular trawl comprises multiple analyte recognition elements in two separate DNA strands, functioning as pincers capable of capturing analytes in a medium. The DNA stem-loop structure reports the amount of bound analyte target through mechanochemical transient events.

Career Highlights

Throughout his career, Hanbin Mao has worked with esteemed institutions such as Kent State University and The Texas A&M University System. His research has focused on advancing the capabilities of biosensing technologies, making significant strides in the field.

Collaborations

Mao has collaborated with notable individuals in his field, including Deepak P Koirala and Hiroshi Sugiyama. These collaborations have contributed to the development of innovative biosensing solutions.

Conclusion

Hanbin Mao's work in biosensing technologies showcases his innovative spirit and dedication to advancing scientific research. His patents reflect a commitment to creating effective and efficient biosensing platforms that have the potential to impact various fields significantly.