Hajime Koyama

Title: Hajime Koyama: Innovator in Virus Inactivation Technologies

Introduction

Hajime Koyama is a notable inventor based in Wakayama, Japan. He has made significant contributions to the field of virus inactivation, holding a total of 3 patents. His work focuses on developing innovative solutions that enhance the safety and efficacy of protein formulations.

Latest Patents

Koyama's latest patents include a virus-inactivating composition that contains a low-molecular weight compound and arginine. This invention provides a virus-inactivating composition with a pH of 3.8 to 5.5, which includes 0.02 to 0.3 M arginine and components such as 0.01 to 10 mM flavonoid, polyphenol, or ascorbic acid derivative, along with 0.005 to 5 mass % of an arginine derivative and 0.1 to 2.5 mass % of an extract solution of a natural product. Another significant patent is a method for inactivating viruses using slightly acidic arginine. This method allows for the convenient production of a protein formulation in which viruses are inactivated without compromising the quality of the protein. It involves exposing the contaminated protein formulation to a 0.1-2M aqueous solution of arginine, adjusted to a pH of 3.5 to 5.

Career Highlights

Koyama is currently employed at Ajinomoto Co., Ltd., a leading company in the food and biotechnology sectors. His work at Ajinomoto has allowed him to focus on innovative research and development in the area of virus inactivation technologies.

Collaborations

Throughout his career, Koyama has collaborated with notable colleagues such as Daisuke Ejima and Tsutomu Arakawa. These collaborations have contributed to the advancement of his research and the successful development of his patents.

Conclusion

Hajime Koyama is a distinguished inventor whose work in virus inactivation technologies has made a significant impact in the field. His innovative patents and contributions to Ajinomoto Co., Ltd. highlight his dedication to enhancing safety in protein formulations.