The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2016

Filed:

Dec. 17, 2013
Applicant:

Ajinomoto Co., Inc., Tokyo, JP;

Inventors:

Hajime Koyama, Wakayama, JP;

Tsutomu Arakawa, Thousand Oaks, CA (US);

Daisuke Ejima, Kawasaki, JP;

Assignee:

AJINOMOTO CO., INC., Tokyo, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 7/06 (2006.01); C12N 7/00 (2006.01); A61K 39/21 (2006.01); A01N 47/44 (2006.01); C12N 7/04 (2006.01); A23L 3/3508 (2006.01); A61K 31/198 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A01N 47/44 (2013.01); A23L 3/3508 (2013.01); A61K 31/198 (2013.01); C12N 7/00 (2013.01); C12N 7/04 (2013.01); C12N 7/06 (2013.01); A23V 2002/00 (2013.01); A61K 2039/5252 (2013.01); C12N 2710/16663 (2013.01); C12N 2760/16163 (2013.01); C12N 2760/18863 (2013.01);
Abstract

The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of contacting a virus-containing object with a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.


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