Haiying Li Grunenwald

Title: Innovations and Contributions of Inventor Haiying Li Grunenwald

Introduction

Haiying Li Grunenwald is a prominent inventor based in Belleville, WI (US), known for her significant contributions to the field of nucleic acid analysis and modification. With a total of 14 patents to her name, she has made remarkable advancements in biotechnology and genetic research.

Latest Patents

One of her latest patents is titled "Transposon end compositions and methods for modifying nucleic acids." This invention provides methods, compositions, and kits for using a transposase and a transposon end to generate extensive fragmentation and 5'-tagging of double-stranded target DNA in vitro. The method allows for the generation of 5′- and 3′-tagged single-stranded DNA fragments without performing a PCR amplification reaction. The first tag on the 5′-ends exhibits the sequence of the transferred transposon end, while the second tag on the 3′-ends exhibits a different sequence. This method is particularly useful for various processes, including metagenomic analysis of DNA in environmental samples and comparative genomic sequencing.

Another notable patent is focused on "Methods of analyzing nucleic acids." This invention presents methods and compositions for analyzing rare nucleic acid species. Some methods utilize DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, including highly abundant and rare sequences.

Career Highlights

Throughout her career, Haiying Li Grunenwald has worked with leading companies in the biotechnology sector, including Illumina Corporation and Epicentre Technologies Corporation. Her work has significantly impacted the development of innovative technologies in genetic research.

Collaborations

She has collaborated with notable professionals in her field, including Nicholas Caruccio and Jerome J. Jendrisak. These collaborations have further enhanced her contributions to the scientific community.

Conclusion

Haiying Li Grunenwald's innovative work in nucleic acid analysis and modification has established her as a leading inventor in biotechnology. Her patents and collaborations continue to influence advancements in genetic research and applications.