Company Filing History:
Years Active: 1998-2006
Title: Haim Zakut: Innovator in Cholinesterase Research
Introduction
Haim Zakut is a prominent inventor based in Savyon, Israel. He has made significant contributions to the field of cholinesterase research, holding a total of 6 patents. His work focuses on innovative methods and systems that enhance our understanding of cholinergic proteins and their implications in therapeutic treatments.
Latest Patents
One of Zakut's latest patents is titled "Transgenic non-human mammals producing a cholinesterase in their milk." This invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding these novel forms of human AChE have been identified in various malignant tumor cells. Additionally, the invention includes a transgenic animal assay system for evaluating the efficacy of drugs against cholinergic proteins prior to or during therapeutic treatment. Transgenic animals, preferably developing tadpoles or mice that express human AChE, are utilized in this system. This assay is also beneficial for assessing the toxicity of substances that may block human AChE, such as organophosphorous compounds.
Another significant patent is the "Method of screening for genetic predisposition to anticholinesterase therapy." This method involves obtaining a peripheral blood sample and analyzing serum from the sample for BuChE levels and inhibitor susceptibilities. Furthermore, the DNA of peripheral white blood cells from the blood sample is screened for the presence of BuChE alleles, thereby identifying patients with a genetic predisposition to anticholinesterase exposure.
Career Highlights
Haim Zakut is associated with Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. His work has been instrumental in advancing the understanding of cholinesterase and its applications in medicine.
Collaborations
Zakut has collaborated with notable colleagues, including Hermona Soreq and Moshe Shani. Their combined expertise has contributed to the success of various research initiatives in the field.
Conclusion
Haim Zakut's innovative research and patents in cholinesterase have made a significant impact on the scientific community. His contributions continue to pave the way for advancements in therapeutic treatments and genetic screening methods.