Company Filing History:
Years Active: 1993-2003
Title: Haim Zaklad: Innovator in Chelation Therapy
Introduction
Haim Zaklad is a notable inventor based in Haifa, Israel, recognized for his contributions to the field of medical therapy and diagnosis. With a total of 10 patents, his work primarily focuses on the synthesis and application of compounds that exhibit chelation affinity for first transition series elements.
Latest Patents
One of Zaklad's latest patents involves the development of compounds with chelation affinity and selectivity for first transition series elements. This invention highlights the synthesis and use of a class of compounds that can decrease the in vivo bioavailability of these elements, aiding in the management of diseases associated with their excess. The compounds have shown potential in inhibiting cell replication in mammalian, bacterial, and fungal cells, making them useful in treating various medical conditions, including neoplasia and infections. Additionally, these compounds can be combined with radioisotopic or paramagnetic cations for use as diagnostic agents in nuclear medicine and MRI.
Another significant patent by Zaklad details processes for synthesizing cyclic and linear polyamine chelators. These polyamines contain nitrogen atoms that are monosubstituted with pendant arms capable of coordinating metal cations. The innovative processes described allow for cyclization over polymerization, even in high-concentration mixtures, and introduce a novel class of N,N′,N″-tris(methylenephosphonate or methylephosphonic acid-substituted)-1,4,7-triazaheptanes.
Career Highlights
Throughout his career, Haim Zaklad has worked with various companies, including Concat Ltd. and Chelator LLC. His expertise in chelation therapy has positioned him as a key figure in the development of innovative medical solutions.
Collaborations
Zaklad has collaborated with notable individuals in his field, including Harry S. Winchell and Joseph Y. Klein. Their combined efforts have contributed to advancements in chelation therapy and related medical applications.
Conclusion
Haim Zaklad's innovative work in the field of chelation therapy has led to significant advancements in medical treatment and diagnosis. His contributions continue to impact the management of diseases associated with first transition series elements, showcasing the importance of his inventions in modern medicine.
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