Haihui Liu

Title: Innovations of Haihui Liu in Pharmaceutical Chemistry

Introduction

Haihui Liu is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of complex compounds. With a total of 2 patents, his work focuses on developing selective inhibitors that have potential applications in drug development.

Latest Patents

Haihui Liu's latest patents include a method for synthesizing furoimidazopyridine compounds. One notable invention is a compound identified as 2-[(2R,5S)-5-[2-methylfuro[3,2-b]imidazo[4,5-d]pyridin-1-yl]tetrahydropyran-2-yl]acetonitrile, which serves as a selective JAK1/TYK2 kinase inhibitor. This compound is synthesized using 7-chloro-6-nitrofuro[3,2-b]pyridine as the starting material, employing nucleophilic substitution, palladium on carbon reduction, and cyclization reactions. The synthesis method is characterized by mild reaction conditions, high product yield, and high purity, making it suitable for industrial production. Additionally, he has developed crystal forms of the compound and its salts, which exhibit favorable physical and chemical properties for drug development.

Career Highlights

Throughout his career, Haihui Liu has worked with notable companies such as Hangzhou Highlight Pharmaceutical Co., Ltd. and Biohaven Therapeutics Ltd. His expertise in pharmaceutical chemistry has allowed him to contribute to various innovative projects and advancements in drug synthesis.

Collaborations

Some of his coworkers include Laibao Wang and Congxin Liang. Their collaborative efforts have further enhanced the research and development of new pharmaceutical compounds.

Conclusion

Haihui Liu's innovative work in the synthesis of pharmaceutical compounds demonstrates his significant impact on drug development. His contributions continue to pave the way for advancements in the field of pharmaceutical chemistry.