Hai U Wang

Title: Innovations of Inventor Hai U Wang

Introduction

Hai U Wang is a prominent inventor based in Folsom, CA (US). He holds a total of 11 patents that contribute significantly to the field of biomedical research. His work primarily focuses on the molecular distinctions between arterial and venous endothelial cells during the early stages of angiogenesis.

Latest Patents

One of his latest patents is titled "Artery- and vein-specific proteins and uses therefor." This patent reveals that arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. The distinction is highlighted by the expression of a transmembrane ligand called EphrinB2 on arterial cells, while its receptor, EphB4, is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Furthermore, it disrupts the remodeling of arteries, indicating that reciprocal interactions between pre-specified arterial and venous endothelial cells are essential for angiogenesis. This distinction can be leveraged in methods to alter angiogenesis, assess the effects of drugs on artery and vein cells, and identify and isolate these cells.

Career Highlights

Throughout his career, Hai U Wang has made significant contributions to the understanding of angiogenesis and endothelial cell biology. His research has implications for developing therapeutic strategies targeting vascular diseases.

Collaborations

Hai U Wang has collaborated with notable professionals in his field, including David J Anderson and Zhoufeng Chen. These collaborations have further enriched his research and innovations.

Conclusion

Hai U Wang's contributions to the field of biomedical research through his patents and collaborations highlight his role as a leading inventor. His work continues to influence the understanding of angiogenesis and its applications in medicine.