Location History:
- Aurburndale, MA (US) (2005)
- Auburndale, MA (US) (1999 - 2010)
- Cambridge, MA (US) (1998 - 2012)
Company Filing History:
21 out of 8,369 
3 out of 2,882 
1 out of 832,680 Years Active: 1998-2012
Title: H. Robert Horvitz: Innovations in Cell Biology and Therapeutics
Introduction
H. Robert Horvitz, based in Auburndale, MA, is a renowned inventor and scientist recognized for his significant contributions to the field of cell biology. With a total of 22 patents to his name, Horvitz has focused much of his work on understanding the mechanisms of cell death and proliferation, paving the way for advancements in therapeutic applications.
Latest Patents
Among his latest patents are notable discoveries regarding the human interleukin-1β convertase (ICE), which reveals a structural similarity to the protein encoded by the cell death gene, ced-3. This patent highlights comparative and mutational analyses of both proteins, suggesting that the Ced-3 may function as a cysteine protease, much like ICE. These findings could lead to novel drugs designed to enhance or inhibit the activity of ICE, ced-3, and related genes, potentially offering treatments for a variety of health issues, including inflammatory diseases, cancers, autoimmune disorders, and even challenges related to hair growth and loss.
Moreover, Horvitz has patented inventions related to the lin-8, lin-56, and lin-61 genes and polypeptides, which play vital roles in cell fate determination and proliferation. This includes methods to diagnose and treat abnormal cell proliferation using the genes and their encoded products.
Career Highlights
Throughout his esteemed career, H. Robert Horvitz has worked at prestigious institutions such as the Massachusetts Institute of Technology and The General Hospital Corporation. His research has not only advanced the scientific community's understanding of cellular processes but has also led to practical developments in medical treatments.
Collaborations
Horvitz has collaborated with distinguished colleagues, including Junying Yuan and Shai Shaham, contributing to multiple research initiatives and enhancing the impact of his work in the scientific arena.
Conclusion
H. Robert Horvitz's innovations continue to shape the landscape of cell biology and therapeutic interventions. His extensive portfolio of patents serves as a testament to his dedication to advancing science and improving human health.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.