Company Filing History:
12 out of 1,186 
1 out of 122 
Years Active: 1994-2008
Title: Gwo-Jenn Shen: Innovator in Carbohydrate Synthesis
Introduction
Gwo-Jenn Shen is a prominent inventor based in Carlsbad, California, known for his significant contributions to the field of carbohydrate synthesis. With a total of 13 patents to his name, Shen has made remarkable advancements in enzymatic production methods, particularly focusing on fucosylated carbohydrates.
Latest Patents
Shen's latest patents include innovative methods for the production of fucosylated carbohydrates through enzymatic fucosylation and the in situ regeneration of GDP-fucose. These inventions aim to enhance the enzymatic production of carbohydrates, especially fucosylated ones. His work also encompasses improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic techniques. The phosphorylated glycosides produced are utilized to create sugar nucleotides, which serve as donor sugars for glycosylation processes. Notably, his methods for fucosylation are particularly emphasized. Additionally, Shen has disclosed the use of KDO aldolase and associated condensation reactions, revealing a broad substrate specificity that allows for the synthesis of various 2-keto-3-deoxy-onic acids, including vital components of lipopolysaccharides found in bacterial membranes.
Career Highlights
Throughout his career, Gwo-Jenn Shen has worked with esteemed institutions such as The Scripps Research Institute and the Scripps Clinic and Research Foundation. His research has significantly impacted the field of carbohydrate chemistry, leading to advancements that have practical applications in biotechnology and medicine.
Collaborations
Shen has collaborated with notable scientists, including Chi-Huey Wong and Yoshitaka Ichikawa, contributing to a rich exchange of ideas and innovations in his field.
Conclusion
Gwo-Jenn Shen's work in carbohydrate synthesis exemplifies the intersection of innovation and practical application in science. His patents and research continue to influence the development of new methods in enzymatic production, showcasing his role as a leading inventor in this specialized area.
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