Guoqing Bao

Title: Guoqing Bao - Innovator in Biopharmaceuticals

Introduction: Guoqing Bao is an accomplished inventor based in Hangzhou, China. He is currently associated with JHM Biopharmaceutical (Hangzhou) Co., Ltd. His work primarily focuses on advancements in biopharmaceuticals, particularly in the development of innovative therapeutic proteins.

Latest Patent Applications: Guoqing Bao has made significant contributions through his latest patent applications. One of his notable applications is for a recombinant botulinum neurotoxin of type A and its preparation method. This application describes a BoNT/A mutant that includes a first peptide fragment and a second peptide fragment linked through an interchain disulfide bond. The first peptide fragment has mutations at specific positions compared to the wild-type BoNT/A, while the second peptide fragment also includes mutations at designated positions. The method involves a series of renaturation treatments to obtain the BoNT/A mutant.

Another significant application is for a growth hormone fusion protein and its preparation method and use. This growth hormone fusion protein features a double-stranded structure with two constant region Fc segments and a growth hormone linked to one of the segments. The design aims to prolong the in vivo half-life of the growth hormone while ensuring higher safety and stronger activity due to the absence of methionine at the N-terminus.

Conclusion: Guoqing Bao's innovative work in the field of biopharmaceuticals showcases his commitment to advancing medical science through his research and patent applications. His contributions are poised to make a significant impact in the industry.