Location History:
- Worcester, MA (US) (2008 - 2022)
- Houghton, MI (US) (2024)
Company Filing History:
7 out of 1,556 
1 out of 881 
Years Active: 2008-2024
Title: Inventor Guiliang Tang: Pioneering Advances in RNA Silencing
Introduction: Guiliang Tang is a notable inventor based in Worcester, MA, known for his significant contributions to the field of RNA silencing. With a total of seven patents, Tang's innovative work is making a substantial impact on plant biology and the design of RNAi-mediated agents. His research is at the forefront of understanding how small RNAs operate within biological systems, paving the way for advancements in genetic engineering and biotechnology.
Latest Patents: One of Guiliang Tang's latest patents focuses on "Methods and compositions for controlling efficacy of RNA silencing." This invention is grounded in a deep understanding of the mechanisms involved in RNA silencing mediated by small RNAs, such as naturally occurring microRNAs (miRNAs). Tang established rules that determine the degree of complementarity required between RNA interference (RNAi)-mediating agents and their target RNA sequences. These rules address whether mismatches are tolerated, the allowable number of mismatches, and the influence of their positions within the RNA strand. This innovative framework is essential for designing enhanced RNAi agents that enable more precise control over RNA silencing efficacy.
Career Highlights: Guiliang Tang's career has been marked by a commitment to research and innovation. His work at the University of Massachusetts has positioned him as a leading figure in his field. The insights gained from his research contribute significantly to advancements in the understanding of RNA biology, with real-world implications for agriculture and biotechnology.
Collaborations: Throughout his career, Tang has collaborated with esteemed colleagues, including Phillip D. Zamore and Dianne S. Schwarz. These partnerships foster an environment of innovation and creativity, enabling the development of groundbreaking technologies in RNA research.
Conclusion: Guiliang Tang stands out as a prominent inventor whose work in RNA silencing is crucial for advancements in biotechnology. With each new patent, he continues to explore methods that enhance our understanding and control of genetic processes, ultimately leading to significant benefits in various scientific applications. His contributions not only advance the field but also inspire upcoming generations of innovators and researchers.