Location History:
- Hsinchu, TW (2006)
- Taipei, TW (2016 - 2017)
Company Filing History:
Years Active: 2006-2017
Title: Innovations in Cancer Treatment by Guang-Huan Sun
Introduction
Guang-Huan Sun is a prominent inventor based in Taipei, Taiwan. He has made significant contributions to the field of pharmaceuticals, particularly in cancer treatment. With a total of three patents to his name, his work focuses on innovative methods and compositions that aim to improve therapeutic outcomes for cancer patients.
Latest Patents
One of Guang-Huan Sun's latest patents involves pharmaceutical compositions and methods for treating cancer. This patent details a combination therapy that includes sorafenib and GW5074. The therapy inhibits cancer cell growth through the c-Raf-PP2A-DAPK signaling transduction pathway. This method has been tested in both in vitro and preclinical animal models, specifically for orthotopic spontaneous kidney cancer, which closely simulates clinical symptoms. The formation of a bond between c-Raf and GW5074 leads to a conformational change that increases the affinity between sorafenib and c-Raf. This binding facilitates the dephosphorylation of DAPK by PP2A, inducing necrosis in cancer cells. Notably, serine 308 of the DAPK protein may serve as a biomarker for drug screening. This innovative study provides a novel pharmaceutical composition and identifies key biomarkers for drug design and screening.
Career Highlights
Guang-Huan Sun is affiliated with the National Defense Medical Center, where he conducts his research and development work. His contributions to the field of cancer treatment have been recognized for their potential to significantly impact patient care and therapeutic strategies.
Collaborations
He has collaborated with notable colleagues, including Sun-Yran Chang and Tai-Lung Cha, to advance research in cancer therapies and drug development.
Conclusion
Guang-Huan Sun's innovative work in pharmaceutical compositions for cancer treatment exemplifies the potential of targeted therapies in modern medicine. His research not only contributes to scientific knowledge but also holds promise for improving the lives of cancer patients.